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A similar effect is achieved by increasing the insulin receptor sensitivity, which may be the basis for treating insulin resistance because, this way, a larger amount of glucose could enter the cells and be converted into energy

Preclinical research has shown that circulating MOTS-c levels are naturally higher in younger individuals and decline with age

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This latter finding is of particular interest, as rather than simply modifying the PDHc, glutarate formed a fatty acid conjugate that binds to the lipoylated catalytic arm of PDHc

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Cleveland Clinic Staff